DAPT

γ-secretase inhibitor

Product Specifications

Background

Inhibitor of γ-secretase; causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. Does not affect APPα and APPβ levels. Blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation.

CAS Number

208255-80-5

Product Name Alternative

N-[ (3,5-Difluorophenyl) acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Neuroscience | Cell Signaling | Neuroscience | Neurodegeneration | Amyloid

Purity

>99%

Weight

0.025

Format

White to off-white powder

Solubility

Soluble to 100 mM in DMSO

Molecular Formula

C23H26F2N2O4

Molecular Weight

432.46

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Dovey H.F., et al. (2001) J. Neurochem. 76(1): 173-81. 2. De Smedt M., et al. (2005) Blood. 106(10): 3498-506. 3. Kanungo J., et al. (2008) J. Neurochem. 106(5): 2236-48.