IOX1
JMJD inhibitor
Product Specifications
Background
IOX1 is a cell permeable inhibitor of the JMJD family of 2-oxoglutarate-dependent histone demethylases (IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 M for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively1). It is a broad spectrum 2-oxoglutarate oxygenase inhibitor which may be used to study hypoxic signaling (1).
CAS Number
5852-78-8
Product Name Alternative
8-Hydroxy-5-quinolinecarboxylic acid; (5-Carboxy-8HQ)
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Epigenetics and Nuclear Signaling
Purity
≥98% (TLC) ; NMR (Conforms)
Weight
0.025
Format
Yellow powder
Solubility
May be dissolved in DMSO (20 mg/ml)
Molecular Formula
C10H7NO3
Molecular Weight
189.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. King O.N., et al. (2010) PLoS One. 5: e15535.
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