Thiolutin

RNA polymerase inhibitor

Product Specifications

Background

Thiolutin is a sulfur antibiotic. Studies show the potential transcriptional inhibition on yeast degradation. By calculating the mRNA decay rates of transcription at different times after inhibition, it was evident that the effect of Thiolutin on the various degradation pathways of mRNA compromises the stability of the mRNA and the mechanism of gene expression (1). In pharmacology is known to inhibit endothelial cell adhesion by perturbing Hsp 27 interactions with components of the actin and intermediate filament cytoskeleton (2). Studies shown the inhibition of tumor cell-induced angionegesis in vivo, adhesion of endothelial cells to vitronectin ( IC50=0.83 µM) (3). Potentially inhibits developmental angiogenesis in zebrafish (2). Cell permeable. Active in vivo. Looking for more information on HSP27? Visit our new HSP27 Scientific Resource Guide at http://www.HSP27.com.

CAS Number

87-11-6

Product Name Alternative

N- (4,5-Dihydro-4-methyl-5-oxo-1,2-d¬ithiolo[4,3-b]pyrrol-6-yl) acetamide

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cell Signaling | Epigenetics and Nuclear Signaling

Purity

≥98% (TLC) ; NMR (Conforms)

Weight

0.001

Format

Yellow powder

Solubility

May be dissolved in DMSO (15 mg/ml)

Molecular Formula

C8H8N2O2S2

Molecular Weight

228.3

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Pelechano V. and Perez-Ortin J. (2008) Yeast 25: 85-92. 2. Jia Y., et al. (2010) Cell Stress Chaperones 15: 165. 3. Minamiguchi K., et al. (2001) International J. Cancer. 93: 307.