Nonactin

Ammonium ionophore

Product Specifications

Background

Nonactin also known as Polynanctin, Werramycin A is a member of the family of cyclic ionophores. It has a high selectivity for ammonium ions and for this reason is also known as “ammonium ionophore”. It was first isolated by Corbaz et al. in 1955 from bacterial strains (1). To understand the required stereochemistry for an efficient bacterial and ion binding, various isothermal calorimetric measurements were performed with K+, Na+ and NH4+. Nonactin is active against a range of gram positive organisms and has a high selectivity for K+ (2).

Product Name Alternative

(1R,2R,5R,7R,10S,11S,14S,16S,19R,20¬R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-O¬ctamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo-[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,3¬0-tetrone

UNSPSC

41116105

Source

Synthetic

Purity

>98% (TLC)

Weight

0.025

Format

White to off-White solid

Solubility

Soluble in DMSO, methanol, ethanol (10 mM), dichloromethane and ethyl acetate. Insoluble in water.

Molecular Formula

C40H64O12

Molecular Weight

736.93

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Corbaz R., et al. (1955) Helvetica Chimica Acta 38(60): 1445-48. 2. Kushe B., Smith A., McGuirl M., Priestley N., (2009) J Am Chem Soc 131(47): 17555-165.