Fasudil
ROCK inhibitor
Product Specifications
Background
Fasudil is a ROCK2 inhibitor with some action on PRK2 and MSK1 (IC50 values are 1.9 µM, 4 µM and 5 µM respectively). It is also shown to inhibit RSK1, RSK2, PKA, AMPK and PKd1. It is also a calcium channel antagonist and vasodilator.
CAS Number
103745-39-7
Product Name Alternative
1- (5-Isoquinolinylsulfonyl) homopiperazine hydrochloride; 5- (1,4-Diazepan-1-ylsulfonyl) isoquinoline
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein
Purity
≥98% (TLC) ; NMR (Conforms)
Weight
0.05
Format
Powder
Solubility
May be dissolved in DMSO (75 mg/ml) or water (100 mg/ml)
Molecular Formula
C14H17N3O2S•HCl
Molecular Weight
327.83
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Shirotani M., et al. (1991) J. Pharmacol. Exp. Ther. 259(2): 738-744.
2. Arai M., Nozawa R., et al. (1993) Biochem. Pharmacol. 46(8): 1487-1490.
3. Satoh S., et al. (1996) Br. J. Pharmacol. 118(7): 1592-1606.
4. Sward K., et al. (2000) J. Physiol. 522: 33-49.
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