Xanthohumol
Autophagy inhibitor
Product Specifications
Background
Xanthohumol is a valosin-containing protein (VCP) inhibitor which binds to the N-domain of VCP, suppressing function and impairing autophagosome maturation (1). It also inhibits growth of a wide variety of human cancer cell lines by inhibiting proliferation and inducing apoptosis (2).
CAS Number
6754-58-1
Product Name Alternative
(2E) -1-[2,4-Dihydroxy-6-methoxy-3- (3-methyl-2-buten-1-yl) phenyl]-3- (4-hydroxyphenyl) -2-propen-1-one
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Autophagy
Purity
≥98% (TLC) ; NMR (Conforms)
Weight
0.01
Format
Yellow solid
Solubility
May be dissolved in DMSO (35 mg/ml) or Ethanol (35 mg/ml)
Molecular Formula
C21H22O5
Molecular Weight
354.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Sasazawa Y., et al. (2012) ACS Chem Biol. 7(5): 892-900. 2. Vene R., et al. (2012) Mol. Med. 18: 1292.
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