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Tranilast

Angiogenesis inhibitor

Product Specifications

Background

Tranilast is an antiallergic, antifibrotic drug that inhibits collagen synthesis, when administered in a dose –dependent manner for a 48 h treatment (1). As an antifibrotic agent, studies shown an effect on the growth of metastasis of mammary carcinoma. It is associated with the inhibition of the growth factor –beta. (TGF-beta) (2).

CAS Number

53902-12-8

Product Name Alternative

2-{[ (2E) -3- (3,4-dimethoxyphenyl) prop-2- enoyl]amino}benzoic acid

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cell Signaling | Neuroscience | Cancer | Cardiovascular System

Purity

≥95% (HPLC)

Weight

0.05

Format

Off-white to yellow powder.

Solubility

Soluble in DMSO.

Molecular Formula

C18H17NO5

Molecular Weight

327.33

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Yamada H., Tajima S., Nishikawa T., Murad S., and Pinnell S., (1999) The Journal of Biochemistrystry. 116(4): 892-897. 2. Chakrabarti R., Subramanian V., Abadalla J., Jothy S., Predhomme GJ. (2009) Anticancer Drugs. 20(5): 334-45.

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