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Nocodazole

Microtubule inhibitor

Product Specifications

Background

Nocodazole also known as Oncodazole. It is an antimitotic agent, associated with the activity of depolymerization of the microtubules (1). Nocadozole has high affinity with Tubulin but little is known on the mechanism of binding. Studies have shown that Nocadozole binds differently to the various α/β isotypes of Tubulin. By measuring the dissociation constants, with the given binding sites, a novel approach of therapeutic agents is under study (2).

CAS Number

31430-18-9

Product Name Alternative

Methyl (5-[2-thienylcarbonyl]-1H-benzimidazol-2-yl

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cancer | Apoptosis | Neuroscience

Purity

≥98% (HPLC) ; NMR (Conforms)

Weight

0.05

Format

White to off-white powder.

Solubility

May be dissolved in DMSO (10 mg/ml, warm)

Molecular Formula

C14H11N3O3S

Molecular Weight

301.3

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Vasquez RJ., Howell B., Yvon AM., Wadsworth P., Cassimus L. (1997) Mol Biol Cell. 8(6): 973-985. 2. Kelian Xu., Schwarz P,. Luduena R,. (2002) Drug Drug Dev.Re. 55: 91-96.

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