Nocodazole
Microtubule inhibitor
Product Specifications
Background
Nocodazole also known as Oncodazole. It is an antimitotic agent, associated with the activity of depolymerization of the microtubules (1). Nocadozole has high affinity with Tubulin but little is known on the mechanism of binding. Studies have shown that Nocadozole binds differently to the various α/β isotypes of Tubulin. By measuring the dissociation constants, with the given binding sites, a novel approach of therapeutic agents is under study (2).
CAS Number
31430-18-9
Product Name Alternative
Methyl (5-[2-thienylcarbonyl]-1H-benzimidazol-2-yl
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis | Neuroscience
Purity
≥98% (HPLC) ; NMR (Conforms)
Weight
0.05
Format
White to off-white powder.
Solubility
May be dissolved in DMSO (10 mg/ml, warm)
Molecular Formula
C14H11N3O3S
Molecular Weight
301.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Vasquez RJ., Howell B., Yvon AM., Wadsworth P., Cassimus L. (1997) Mol Biol Cell. 8(6): 973-985.
2. Kelian Xu., Schwarz P,. Luduena R,. (2002) Drug Drug Dev.Re. 55: 91-96.
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