PJ-34
PARP inhibitor
Product Specifications
Background
PJ-34 is a selective inhibitor of Poly (ADP-Ribose) polymerase (PARP). Studies have shown that the use of PJ-34 on severe inflammatory diseases, in particular experimental allergic encephalomyelitis (EAE) have contributed to a shift of the immune response from a pro-inflammatory Th1 to anti-inflammatory th2 phenotype (1).
CAS Number
344458-15-7
Product Name Alternative
N- (6-Oxo-5,6-dihydrophenanthridin-2-yl) -N, Ndimethylacetamide . HCl
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis | Cancer Growth Inhibitors | PARP Inhibitors
Purity
≥98% (HPLC) ; NMR (Conforms)
Weight
0.05
Format
White to yellow solid.
Solubility
May be dissolved in DMSO (30 mg/ml) or water (20 mg/ml)
Molecular Formula
C17H17N3O2•HCL•H2O
Molecular Weight
331.8
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Scott G., Kean R., Mikheeva., Fabis M., Mabley J.J. (2004) The Journal of Pharmacology and Exp. Therapeutics. 310(3): 1053-1061.
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