Huperzine A
ACH inhibitor
Product Specifications
Background
Huperzine A is an acetylcholinesterase inhibitor. It is known for enhancing learning and memory by protecting a neurotransmitter molecule in the brain. Huperzine is also a NMDA glutamate receptor antagonist (1-2). The effects on the treatment of Alzheimer's disease is under studies (1-3). Recent studies of Huperzine A highlight the potential therapeutic use for dementia by slowing down the neuronal cell death caused by glutamate (4).
CAS Number
102518-79-6
Product Name Alternative
(1R,9S,13E) - 1-Amino- 13-ethylidene- 11-methyl- 6-azatricyclo[7.3.1.02,7] trideca- 2 (7),3,10- trien- 5-one
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience | Ion Channels | Neurotransmitter Receptors | Neurodegeneration | Alzheimer's Disease | Glutamate Receptors | NMDA Receptors
Purity
>95% (HPLC) ; NMR (conforms)
Weight
0.005
Format
Off-White solid
Solubility
Soluble in DMSO, methanol or ethanol.
Molecular Formula
C15H18N2O
Molecular Weight
242.32
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Bai Dl., Tang Xc., He YC., Curr MedChem. (2000) 7(3): 355-74.
2. Tang L., Wang r., Tang x., (2005) Acta Acta Pharmacologica 26(6): 673-678.
3. Ved Hs,. Koenig ml., Dave JR., Doctor BP.(1997) Neurorport. 8(4): 963-8.
4. Li WM., Kan KK., Carlier PR., Pang YP., Han YF. YF., (2007) Curr Alzheimer Res. 4: 386-396.
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