Carnosic acid
PPARγ activator
Product Specifications
Background
Carnosic acid is a benzenediol abietane diterpene naturally extracted from rosemary (Rosmarinus officinalis) and sage (Saliva officinalis). It is a potent antioxidant that inhibits NADH or NADPH induced lipid peroxidation by acting as a free radical scavenger (1). It has been found to increase cellular levels of glutathione (GSH) and prevent 6-hydroxydopamine-induced cell death in SH-SY5Y cells (2). Carnosic acid-stimulation of GSH also inhibits adipocyte differentiation (3). It has also been found to induce apoptosis (4) and inhibit the proliferation and migration of various tumor cell lines (5).
CAS Number
3650-09-7
Product Name Alternative
(4aR,10aS) -5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,3,4,9,10,10a-hexahydro-2H-phenanthrene-4a-carboxylic acid
UNSPSC
41116105
Type
Activator
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
≥95% (HPLC) ; NMR (Conforms)
Weight
0.05
Format
Off white to yellow solid
Solubility
Soluble in DMSO (50 mg/ml)
Molecular Formula
C20H28O4
Molecular Weight
332.43
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Schwarz K., Ternes W. (1992) Zeitschrift für Lebensmittel-Untersuchung und –Forschung. 195 (2): 99-103.
2. Chen J.H., et al. Chem. (2012) Res. Toxicol 25:1893.
3. Takahashi T., et al. (2009) Biochem. Biophys. Res. Commun. 382:549.
4. Kar S., et al. (2012) Apoptosis. 17:1735.
5. Barni M.V., et al. (2012) Oncol. Rep. 27:1041.
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