Sodium Valproate
HDAC inhibitor
Product Specifications
Background
Histone deacetylase inhibitor (IC50=400 µM). Demonstrates neuroprotective, anticancer and anti-inflammatory activity. Inhibits Aβ production and neuritic plaque formation in Alzheimer's mouse models. Clinically useful anticonvulsant.
CAS Number
1069-66-5
Product Name Alternative
2-Propylpentanoic acid Na
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Epigenetics and Nuclear Signaling | Cancer
Purity
>98% (TLC), NMR conforms
Weight
5
Format
White Solid
Solubility
Soluble in 50 mg/ml Water
Molecular Formula
C8H15NaO2
Molecular Weight
166.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Phiel C.J., et al. (2001) J. Biol. Chem. 276: 36734.
2. Kim H.J., et al. (2007) J. Pharmacol. Exp. Ther. 321: 892.
3. Qing H., et al. (2008) J. Exp. Med. 205: 2781.
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