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Garcinol

HAT inhibitor

Product Specifications

Background

Potent inhibitor of histone acetyl transferases p300 (IC50=7 mM) and pCAF (IC50=5 mM) (1). Induces apoptosis in various cell lines (2). Promotes expansion of human hematopoietic stem cells(3). Cell permeable.

CAS Number

78824-30-3

Product Name Alternative

Camboginol, 3-​ (3, ​4-​dihydroxybenzoyl) -​4-​hydroxy-​8, ​8-​dimethyl-​1, ​7-​bis (3-​methyl-​2-​buten-​1-​yl) -​5-​[ (2S) -​5-​methyl-​2-​ (1-​methylethenyl) -​4-​hexen-​1-​yl]-​bicyclo[3.3.1]non-​3-​ene-​2, ​9-​dione

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cell Signaling | Epigenetics and Nuclear Signaling

Purity

>98% (TLC), NMR conforms

Weight

0.005

Format

Yellow solid

Solubility

Soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol

Molecular Formula

C38H50O6

Molecular Weight

602.8

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Balasubramanyam K., et al., (2004) J. Biol. Chem. 279: 33716. 2. Parasramka M.A., et al. (2011) Nutr. Cancer. 63: 456. 3. Nishino T., et al. (2011) Nutr. PLoS One 6: e24298.

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