Garcinol
HAT inhibitor
Product Specifications
Background
Potent inhibitor of histone acetyl transferases p300 (IC50=7 mM) and pCAF (IC50=5 mM) (1). Induces apoptosis in various cell lines (2). Promotes expansion of human hematopoietic stem cells(3). Cell permeable.
CAS Number
78824-30-3
Product Name Alternative
Camboginol, 3- (3, 4-dihydroxybenzoyl) -4-hydroxy-8, 8-dimethyl-1, 7-bis (3-methyl-2-buten-1-yl) -5-[ (2S) -5-methyl-2- (1-methylethenyl) -4-hexen-1-yl]-bicyclo[3.3.1]non-3-ene-2, 9-dione
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Epigenetics and Nuclear Signaling
Purity
>98% (TLC), NMR conforms
Weight
0.025
Format
Yellow solid
Solubility
Soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol
Molecular Formula
C38H50O6
Molecular Weight
602.8
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Balasubramanyam K., et al., (2004) J. Biol. Chem. 279: 33716.
2. Parasramka M.A., et al. (2011) Nutr. Cancer. 63: 456.
3. Nishino T., et al. (2011) Nutr. PLoS One 6: e24298.
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