FK-866 HCl
NAD biosynthesis inhibitor
Product Specifications
Background
Nicotinamide phosphoribosyltransferase inhibitor (Ki=0.4 nM). Induces tumor cell apoptosis. Extends lifespan of human cells. Cell permeable.
Product Name Alternative
(E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)acrylamide, FK866 hydrochloride hydrate, K22.175
UNSPSC
41116105
Source
Synthetic
Purity
>98% (TLC), NMR conforms
Weight
0.005
Format
White Solid
Solubility
Soluble in 40 mg/ml Water
Molecular Formula
C24H29N3O2•HCl
Molecular Weight
428
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Hasmann M., et al. (2003) Cancer Res. 63: 7436. 2. van der Veer E., et al. (2007) J. Biol. Chem. 282: 10841.
CAS Number
658084-64-1
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