EX-527
SIRT1 inhibitor
Product Specifications
Background
Selective SIRT1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation following DNA damage. Cell permeable.
CAS Number
49843-98-3
Product Name Alternative
6-Chloro-2,3,4,9-tetrahydro-1Hcarbazole-1-carboxamide (racemic)
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Epigenetics and Nuclear Signaling
Purity
>98% (TLC), NMR conforms
Weight
0.005
Format
Light Yellow Solid
Solubility
Soluble in 18 mg/ml DMSO or 10 mg/ml Ethanol
Molecular Formula
C13H13ClN2O
Molecular Weight
248.7
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Solomon J.M., et al., (2006) Mol. Cell. Biol. 26: 28. 2. Anderson J.L., et al., (2011) Mol.Cell 43: 834.
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