C-646
HAT inhibitor
Product Specifications
Background
Potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. Enhances fear extinction memory and synaptic plasticity in mice. Promotes tau deacetylation reducing levels of pathogenic p-tau. Cell permeable.
CAS Number
328968-36-1
Product Name Alternative
4-[4-[[5- (4,5-Dimethyl-2-nitrophenyl) -2-furanyl]methylene]- 4,5-dihydro-3-methyl-5-oxo-1Hpyrazol- 1-yl]benzoic acid
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Epigenetics and Nuclear Signaling
Purity
>98% (TLC), NMR conforms
Weight
0.005
Format
Orange Solid
Solubility
Soluble in 10 mg/ml DMSO
Molecular Formula
C24H19N3O6
Molecular Weight
445.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Bowers E.M., et al. (2010) Chem. Biol. 17: 471.
2. Santer F.R., et al. (2011) Mol. Cancer Ther. 10: 1644.
3. Marek R., et al. (2011) J. Neurosci. 31: 7486.
4. Min S.W., et al. (2010) Neuron 67: 953.
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