C-646

HAT inhibitor

Product Specifications

Background

Potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. Enhances fear extinction memory and synaptic plasticity in mice. Promotes tau deacetylation reducing levels of pathogenic p-tau. Cell permeable.

CAS Number

328968-36-1

Product Name Alternative

4-[4-[[5- (4,5-Dimethyl-2-nitrophenyl) -2-furanyl]methylene]- 4,5-dihydro-3-methyl-5-oxo-1Hpyrazol- 1-yl]benzoic acid

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cell Signaling | Epigenetics and Nuclear Signaling

Purity

>98% (TLC), NMR conforms

Weight

0.025

Format

Orange Solid

Solubility

Soluble in 10 mg/ml DMSO

Molecular Formula

C24H19N3O6

Molecular Weight

445.4

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Bowers E.M., et al. (2010) Chem. Biol. 17: 471. 2. Santer F.R., et al. (2011) Mol. Cancer Ther. 10: 1644. 3. Marek R., et al. (2011) J. Neurosci. 31: 7486. 4. Min S.W., et al. (2010) Neuron 67: 953.