BIX-01294

G9a-like protein and G9a histone lysine methyltransferase inhibitor (IC values are 0.7 and 1.7 µM respectively) that displays no activity at other histone methyltransferases up to 37 µM. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro.

2- (Hexahydro-4-methyl-1H-1,4-diazepin-1-yl) -6,7-dimethoxy-N-[1- (phenylmethyl) -4-piperidinyl]-4-quinazolinamine trihydrochloride; N- (1-Benzyl-4-piperidinyl) -6,7-dimethoxy-2- (4-methyl-1,4-diazepan-1-yl) -4-quinazolinamine trihydrochloride

1. Kubicek S., et al. (2007) Mol Cell. 25(3): 473-481. 2. Shi Y., et al. (2008) Cell Stem Cell. 3(5): 568-574. 3. Chang Y., et al. (2009) Nat Struct Mol Biol. 16(3): 312-317.