Apicidin
HDAC inhibitor
Product Specifications
Background
Cyclopeptide inhibitor of histone deactylases (HDACs). Inhibits HeLa cell proliferation (IC50=50-100 nM) and induces reversible transcriptional activation of p21 (WAF1). Decreases HIF1α protein levels and transcriptional activity in human and mouse tumor cell lines. Cell permeable.
CAS Number
183506-66-3
Product Name Alternative
(3S,6S,9S,15aR) -9-[ (2S) -2-Butanyl]-6-[ (1-methoxy-1H-indol-3-yl) methyl]-3- (6-oxooctyl) octahydro-2H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10 (3H,12H) -tetrone; Cyclo (N-O-methyl-L-tryptophanyl-L Lisoleucinyl-Dpipecolinyl-L-2-amino-8-oxodecanoyl)
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Epigenetics and Nuclear Signaling | Cancer
Purity
>98% (HPLC) ; NMR (conforms)
Weight
0.005
Format
White Solid
Solubility
Soluble in 10 mg/ml DMSO or 100% Ethanol
Molecular Formula
C34H49N5O6
Molecular Weight
623.8
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Darkin-Rattray S.J., et al. (1996) Proc. Natl. Acad. Sci. USA. 93: 13143.
2. Han J.W., et al. (2000) Cancer Res. 60: 6068.
3. Kim S.H., et al. (2007) Oncol. Rep. 17: 647.
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