5-Azacytidine
DNA hypomethylation agent
Product Specifications
Background
DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.
Product Name Alternative
4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; Ladakamycin; U- 18496; NSC-102816; 5-AzaC
UNSPSC
41116105
Source
Synthetic
Purity
>98% (TLC); NMR (Conforms)
Weight
0.05
Format
White Solid
Solubility
Soluble in 25 mg/ml DMSO or 12 mg/ml Water
Molecular Formula
C8H12N4O5
Molecular Weight
244.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Schneider-Stock R., et al. (2005) J Pharmacol Exp Ther. 312(2): 525-536.
2. Mikkelsen T.S., et al., (2008) Nature. 454(7200): 49-55.
3. Qian Q., et al., (2012) Stem Cells Dev. 21(1): 67-75.
CAS Number
320-67-2
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