Nutlin-3
P53/mdm2 inhibitor
Product Specifications
Background
MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 µM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.
CAS Number
548472-68-0
Product Name Alternative
(±) -4-[4,5-Bis (4-chlorophenyl) -2- (2-isopropoxy-4-methoxy-phenyl) -4,5- dihydro-imidazole -1-carbonyl]-piperazin-2-one
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis | Cancer Growth Inhibitors | p53/mdm2 Inhibitors
Purity
>98%
Weight
0.005
Format
Yellow solid
Solubility
Soluble in 100 mM DMSO and Ethanol
Molecular Formula
C30H30Cl2N4O4
Molecular Weight
581.9
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Vassilev et al (2004) Science 303: 844.
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