B-AP15

Deubiquitinase (DUB) Inhibitor (NSC-687852)

Product Specifications

Background

Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. b-AP15 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.

CAS Number

1009817-63-3

Product Name Alternative

(3E,5E) -1-Acryloyl-3,5-bis (4-nitrobenzylidene) -4-piperidinone

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cancer | Apoptosis

Purity

>98%

Weight

0.005

Format

Pale Yellow Solid

Solubility

Soluble in 35 mg/ml DMSO

Molecular Formula

C22H17N3O6

Molecular Weight

419.4

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. D'Arcy P., et al. (2011) Nature Medicine 17: 1636.

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