WP1130
Deubiquitinase (DUB) Inhibitor
Product Specifications
Background
A novel DUB inhibitor directly inhibiting USP9x, USP5, USP14 and UCH37 inducing rapid accumulation of polyubiquitinated proteins. Blocks Jak2 signaling via Jak2 ubiquitination.
CAS Number
856243-80-6
Product Name Alternative
(2E) -3- (6-bromopyridin-2-yl) -2-cyano-N- (1-phenylbutyl) acrylamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
>98%
Weight
0.005
Format
Pale Yellow Solid
Solubility
Soluble in 45 mg/ml DMSO, 25 mg/ml Ethanol
Molecular Formula
C19H18BrN3O
Molecular Weight
384.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. KapuriaV., et al. (2010) Cancer Res. 70: 9265. 2. Kapuria V., et al. (2011) Cell Signal. 23: 2076.
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