Celastrol
Proteasome inhibitor
Product Specifications
Background
Displays potent antioxidant and anti-inflammatory activity. Inhibits NFB (IC50=270 nM). It induces heat shock response and cytoprotection in various cells. It inhibits 20S proteasome chymotrypsin activity (IC50=2.5 M). Cell permeable.
CAS Number
34157-83-0
Product Name Alternative
3-hydroxy-9β, 13α-dimethyl-2-oxo-24, 25, 26-trinoroleana-1 (10), 3, 5, 7-tetraen-29-oic acid, 10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid, Tripterin
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis | Cancer Growth Inhibitors | Proteasome Inhibitors
Purity
>98%
Weight
0.01
Format
Red Powder
Solubility
Soluble in 45 mg/ml DMSO, 30 mg/ml Ethanol
Molecular Formula
C29H38O4
Molecular Weight
450.6
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Sethi G., et al. (2007) Blood109: 2727.
2. Westerheide S.D., et al. (2004) J. Biol. Chem. 279: 56053.
3. Yang H., et al. (2006) Cancer Res. 66: 4758.
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