LDN-57444
DUB inhibitor
Product Specifications
Background
Inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 M). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. Cell permeable.
CAS Number
668467-91-2
Product Name Alternative
3- (O-acetyloxime), 5-chloro-1-[ (2,5-dichlorophenyl) methyl]-1H-Indole-2,3-dione, C30, LDN 57444
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
>98%
Weight
0.05
Format
Yellow Powder
Solubility
Soluble in 20 mg/ml DMSO
Molecular Formula
C17H11Cl3N2O3
Molecular Weight
397.6
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Liu Y., et al. (2003) Chem. Biol. 10: 837.
2. Tan Y.Y., et al. (2008) Mol. Cell. Biochem. 318: 109.
3. Cartier A.E., et al. (2009) J.Neurosci. 29: 7857.
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