LDN-57444

DUB inhibitor

Product Specifications

Background

Inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 M). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. Cell permeable.

CAS Number

668467-91-2

Product Name Alternative

3- (O-acetyloxime), 5-chloro-1-[ (2,5-dichlorophenyl) methyl]-1H-Indole-2,3-dione, C30, LDN 57444

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cancer | Apoptosis

Purity

>98%

Weight

0.01

Format

Yellow Powder

Solubility

Soluble in 20 mg/ml DMSO

Molecular Formula

C17H11Cl3N2O3

Molecular Weight

397.6

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Liu Y., et al. (2003) Chem. Biol. 10: 837. 2. Tan Y.Y., et al. (2008) Mol. Cell. Biochem. 318: 109. 3. Cartier A.E., et al. (2009) J.Neurosci. 29: 7857.