Lactacystin
Proteasome inhibitor
Product Specifications
Background
Specific inhibitor of three proteolytic activities of the proteasome. Chymotrypsin-like activity is inhibited most potently followed by trypsin-like activity. Peptidyl-glutamyl peptide hydrolytic activity is relatively weak.
CAS Number
133343-34-7
Product Name Alternative
(2R,3S,4R) -3-Hydroxy-2-[ (1S) -1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxy-N-acetyl-L-cysteine thioester
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis | Cancer Growth Inhibitors | Proteasome Inhibitors
Purity
>98%
Weight
0.001
Format
White Solid
Solubility
Soluble in DMSO, Water or Ethanol
Molecular Formula
C15H24N2O7S
Molecular Weight
376.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Omura S., et al. (1991) J. Antibiot. 44: 113. 2. Fenteany G., et al. (1995) Science 268: 726
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