Pifithrin mu
Hsp70 inhibitor
Product Specifications
Background
Selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. It induces apoptosis and is cell permeable. Also, inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
CAS Number
64984-31-2
Product Name Alternative
2-Phenylethynesulfonamide, PFTµ
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Heat Shock
Purity
>98%
Weight
0.05
Format
White to off-white solid
Solubility
Soluble in ethanol (110 mM) and in DMSO (110 mM)
Molecular Formula
C8H7NO2S
Molecular Weight
181.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Leu J.L., et al. (2009) Mol. Cell. 36: 15.
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