Capsaicin
TRPV1opener
Product Specifications
Background
Capsaicin is an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel (1, 2). It exhibits neuroprotective effects in a model of transient global cerebral ischemia and induces release of substance P from afferent nociceptive specific neurons (1). Powerful excitant of peripheral sensory nerve endings, specifically unmyelinated afferent neurons (C-fibers). Reversibly inhibits aggregation of platelets (3).
CAS Number
404-86-4
Product Name Alternative
(6E) -N- (4-Hydroxy-3-methoxybenzyl) -8-methyl-6-nonenamide, 8-Methyl-N-vanillyl-trans-6-nonenamide
UNSPSC
41116105
Type
Small Molecules
Source
Synthetic
Field of Research
Neuroscience | Ion Channels | Transient Receptor Potential (TRP) Channels
Purity
>60% (HPLC) ; NMR (conforms)
Weight
0.2
Format
Off-White Solid
Solubility
Soluble in DMSO (20 mg/mL) and ethanol (15 mg/mL)
Molecular Formula
C18H27NO3
Molecular Weight
305.41
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Caterina M.J., et al. (1997) Nature. 389(6653): 816-824.
2. Story G.M., Crus-Orengo L. (2007) Am Scientist. 95(4): 326-333.
3. Vaishnava P., Wang D.H. (2003) Curr Med Chem Cadiovasc Hematol Agents. 1(2): 177-188.
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