2-APB
TRP blocker
Product Specifications
Background
2-APB is a chemical that acts to inhibit IP3 receptors (1) and TRP channels (2). It is used to manipulate intracellular release of calcium ions and modify TRP channel activity. There is also evidence that 2-APB acts directly to inhibit gap junctions made of connexin26 or connexin32 (3).
CAS Number
524-95-8
Product Name Alternative
2-Aminoethoxydiphenylborane
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience | Ion Channels | Transient Receptor Potential (TRP) Channels
Purity
>98%
Weight
0.05
Format
White solid
Solubility
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Molecular Formula
C14H16BNO
Molecular Weight
225.1
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Diver J.M., Sage S.O., Rosado J.A. (2001) Cell Calcium. 30(5): 323-329
2. Xu S.Z., et al. (2005) Br J Pharamcol. 145(4): 320-328.
3. Tao L., and Harris A.L. (2007) Mol Pharmacol. 71(2): 570-579.
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