2-APB

TRP blocker

Product Specifications

Background

2-APB is a chemical that acts to inhibit IP3 receptors (1) and TRP channels (2). It is used to manipulate intracellular release of calcium ions and modify TRP channel activity. There is also evidence that 2-APB acts directly to inhibit gap junctions made of connexin26 or connexin32 (3).

CAS Number

524-95-8

Product Name Alternative

2-Aminoethoxydiphenylborane

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Neuroscience | Ion Channels | Transient Receptor Potential (TRP) Channels

Purity

>98%

Weight

0.25

Format

White solid

Solubility

Soluble to 100 mM in DMSO and to 10 mM in ethanol

Molecular Formula

C14H16BNO

Molecular Weight

225.1

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Diver J.M., Sage S.O., Rosado J.A. (2001) Cell Calcium. 30(5): 323-329 2. Xu S.Z., et al. (2005) Br J Pharamcol. 145(4): 320-328. 3. Tao L., and Harris A.L. (2007) Mol Pharmacol. 71(2): 570-579.