KB-R7943 mesylate
TRPC channel blocker
Product Specifications
Background
KN-R9743 mesylate is a potent selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger. It also inhibits the mitochondrial Ca2+ uniporter. It does not affect Na+ dependent transport systems or ionotropic glutamate receptors.
CAS Number
182004-65-5
Product Name Alternative
2-{4-[ (4-Nitrobenzyl) oxy]phenyl}ethyl carbamimidothioate methanesulfonate (1:1)
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience | Ion Channels | Transient Receptor Potential (TRP) Channels
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.01
Format
White Solid
Solubility
Soluble to 100 mM in DMSO
Molecular Formula
C16H17N3O3S•CH3SO3H
Molecular Weight
427.29
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Hoyt K.R., Arden S.R., Aizenman E. and Reynolds I.J. (1998) Mol Pharmacol. 53(4): 742-749.
2. Schroder U.H., Breder J, Sabelhaus C.F., Reymann K.G. (1999) Neuropharm. 38(2): 319-321.
3. Watano T., Harada Y., Harada K., Nishimura N. (1999) Br J Pharmacol. 127(8): 1846-1850.
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