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KB-R7943 mesylate

TRPC channel blocker

Product Specifications

Background

KN-R9743 mesylate is a potent selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger. It also inhibits the mitochondrial Ca2+ uniporter. It does not affect Na+ dependent transport systems or ionotropic glutamate receptors.

CAS Number

182004-65-5

Product Name Alternative

2-{4-[ (4-Nitrobenzyl) oxy]phenyl}ethyl carbamimidothioate methanesulfonate (1:1)

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Neuroscience | Ion Channels | Transient Receptor Potential (TRP) Channels

Purity

>98% (TLC) ; NMR (Conforms)

Weight

0.01

Format

White Solid

Solubility

Soluble to 100 mM in DMSO

Molecular Formula

C16H17N3O3S•CH3SO3H

Molecular Weight

427.29

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Hoyt K.R., Arden S.R., Aizenman E. and Reynolds I.J. (1998) Mol Pharmacol. 53(4): 742-749. 2. Schroder U.H., Breder J, Sabelhaus C.F., Reymann K.G. (1999) Neuropharm. 38(2): 319-321. 3. Watano T., Harada Y., Harada K., Nishimura N. (1999) Br J Pharmacol. 127(8): 1846-1850.

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