SKF-96365
TRPC channel blocker
Product Specifications
Background
SKF-96365 is a selective inhibitor of receptor mediated Ca2+ entry and voltage-gated Ca2+ entry (1). It has also been shown o inhibit cytochrome P-450 mediated reactions (1,2), and reversibly activates non-selective cation channels in human endotherlial cells (1,3).
CAS Number
130495-35-1
Product Name Alternative
1-{2- (4-Methoxyphenyl) -2-[3- (4-methoxyphenyl) propoxy]ethyl}-1H-imidazole hydrochloride (1:1)
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience | Ion Channels | Transient Receptor Potential (TRP) Channels
Purity
>98%
Weight
0.025
Format
White solid
Solubility
Soluble to 100 mM in water
Molecular Formula
C22H26N2O3.HCl
Molecular Weight
402.92
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Leis H.J., et al. (1995) Br J Pharmacol. 114(3): 598-601.
2. Sheets J.J., Mason J.I., Wise C.A. and Eastabrook R.W. (1986) Biochem Pharmacol. 35: 487-491.
3. Schwarz G., Droogmans G. and Nilius B. (1994) Cell Calcium. 15: 45-54.
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