Astemizole
Herg channel blocker
Product Specifications
Background
Astemizole is a second generation antihistamine drug which has a long duration of action. It binds to histamine H1-receptor sites in the gastrointestinal tract, uterus, blood vessels and bronchial muscle. It does not cross the blood-brain barrier, and the binding is primarily in the peripheral nervous system (1). It is metabolized by CYP3A4 (2).
Product Name Alternative
1-(4-Fluorobenzyl)-N-{1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl}-1H-benzimidazol-2-amine, Hismanal
UNSPSC
41116105
Source
Synthetic
Purity
>98%
Weight
0.05
Format
White solid
Solubility
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Molecular Formula
C28H31FN4O
Molecular Weight
458.57
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Laduron P.M., Janssen P.F., Commeren W. and Leysen J.E. (1982) Mol Pharmacol. 21(2): 294-300.
2. Maysumoto S., Yamazoe Y. (2001) Br. J Clin Pharamcol. 51(2): 133-142.
CAS Number
68844-77-9
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