A-967079
TRPA1 blocker
Product Specifications
Background
A-967079 is a TRPA1 antagonist (1) and cell permeable. It has been found to be a potent blocker of TRPA1 channels. It is an oxime analogue and resembles AP18 from a structural perspective, although it has a methyl addition and a chlorine–fluorine substitution. However, compared with AP18 and HC-030031, A-967079 is significantly more potent (100-fold on human and 24-fold on rat TRPA1) and has a much improved pharmacokinetic profile. A-967079 is also more selective, with >1000-fold selectivity over other TRP channels and >150-fold selectivity over 75 other tested proteins (2).
Product Name Alternative
(1E,3E)-1-(4-Fluorophenyl)-N-hydroxy-2-methyl-1-penten-3-imine
UNSPSC
41116105
Source
Synthetic
Purity
>98%
Weight
0.01
Format
White solid
Solubility
Soluble in DMSO (25 mg/ml)
Molecular Formula
C12H14FNO
Molecular Weight
207.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. McGaraughty S., et al. (2010) Mol Pain. 6: 14. 2. Chen et al. (2011) PAIN. 152: 1165–1172.
CAS Number
1170613-55-4
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