Resveratrol

Resveratrol is a stilbenoid and a phytoalexin produced naturally by several plants. Its effects are numerous and include anti-cancer (1), anti-inflammatory (2), anti-fungal and has other beneficial cardiovascular effects. It has been proposed that Mn SOD is increased by the pathwayRESV-SIRT1/Nad+- FOXO3a- MnSOD (3). In terms of its anti-cancer properties, resveratrol modulates the transcription factor NF-KB and inhibition of the cytochrome P450 enzyme (1, 4). It also enhances hippocampal neurogenesis.

1. Leiro J., et al. (2005) Int Immunopharm. 5(2): 393-406. 2. Gentilli M., et al. (2001) Life Sciences. 68(11): 1317-1321. 3. Robb E.L., et al. (2008) Biochem Biophys Res Commun. 367(2): 406-412. 4. Chun Y.J., Kim M.Y., Guengerich F.P. (1999) Biochem Biophys Res Commun. 262(1): 20-24.