Troglitazone
PPARgamma agonist
Product Specifications
Background
Troglitazone, a member of the thaizolidinediones, is an anti-diabetic and anti-inflammatory drug. It works by activating peroxisome proliferator-activated receptors (PPARs) (1). It is a ligand to both PPARalpha and gamma. It also contains an alpha-tocopheroyl moiety, potentially giving it vitamin E like activity (which helps in inflammation) (2).
CAS Number
97322-87-7
Product Name Alternative
5-{4-[ (6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl) methoxy]benzyl}-1,3-thiazolidine-2,4-dione, Rezulin
UNSPSC
41116105
Type
Agonist
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
>98%
Weight
0.05
Format
White solid
Solubility
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Molecular Formula
C24H27NO5S
Molecular Weight
441.54
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Lambe K.G. and Tugwood J.D. (1996) Eur J Biochem. 239(1): 1-7. 2. Aljada A., et al. (2001) J Clin Endocrinol Metab. 86(7): 3250-3256.
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