Phenylbutyrate Na

HDAC inhibitor

Product Specifications

Background

Sodium phenylbutyrate is metabolized in the human body by beta-oxidation to phenylacetate, which is then conjugated with glutamine to phenylacetylglutamine, which is eliminated with urine (1). It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of gamma-globin gene (2). It has been shown to reduce tau pathology in an Alzheimer's Disease model (3).

CAS Number

1716-12-7

Product Name Alternative

Sodium 4-phenylbutanoate, 4-PB

UNSPSC

41116105

Type

Inducer

Source

Synthetic

Field of Research

Purity

>98%

Weight

0.1

Format

White solid

Solubility

Soluble to 1100 mM in water and 100 mM in DMSO

Molecular Formula

C10H11NaO2

Molecular Weight

186.18

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Batashaw M.L., MacArthur R.B., and Tuchman M. (2001) J Pediatr. 138: S46-54. 2. Melichar B., et al. (1998) Clin Cancer Res. 4:3069-3076. 3. Ricobaraza A., et al. (2009) Neuropsychopharmacology. 34, 1721-1732.