Phenylbutyrate Na
HDAC inhibitor
Product Specifications
Background
Sodium phenylbutyrate is metabolized in the human body by beta-oxidation to phenylacetate, which is then conjugated with glutamine to phenylacetylglutamine, which is eliminated with urine (1). It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of gamma-globin gene (2). It has been shown to reduce tau pathology in an Alzheimer's Disease model (3).
CAS Number
1716-12-7
Product Name Alternative
Sodium 4-phenylbutanoate, 4-PB
UNSPSC
41116105
Type
Inducer
Source
Synthetic
Field of Research
Cancer | Apoptosis | Cancer Growth Inhibitors | HDAC Inhibitors | Neuroscience | Neurodegeneration | Alzheimer's Disease | Tangles & Tau
Purity
>98%
Weight
0.1
Format
White solid
Solubility
Soluble to 1100 mM in water and 100 mM in DMSO
Molecular Formula
C10H11NaO2
Molecular Weight
186.18
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Batashaw M.L., MacArthur R.B., and Tuchman M. (2001) J Pediatr. 138: S46-54.
2. Melichar B., et al. (1998) Clin Cancer Res. 4:3069-3076. 3. Ricobaraza A., et al. (2009) Neuropsychopharmacology. 34, 1721-1732.
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