Trichostatin A
HDAC inhibitor
Product Specifications
Background
Trichostatin A is an antifungal and selectively inhibits the class I and II mammalian histon deacetlyase families of enzymes (1). TSA inhibits the eukayotic cell cycle during the beginning of the growth stage. It can be used to alter gene expression but interfering with the removal of acetyl groups thereby altering the ability of DNA transcription factors to access the DNA inside chromatin (2). It also has anti-cancer properties (3).
CAS Number
58880-19-6
Product Name Alternative
(2E,4E,6R) -7-[4- (Dimethylamino) phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis | Cancer Growth Inhibitors | HDAC Inhibitors
Purity
>98%
Weight
0.005
Format
Beige Solid
Solubility
Soluble to 10 mM in ethanol and to 50 mM in DMSO
Molecular Formula
C17H22N2O3
Molecular Weight
302.37
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Vanhaecke T., Papeleu P., Elaut G., Rogiers V. (2004) Curr Med Chem. 11(12): 1629-1643.
2. Yoshida, et al. (1990) J Biol Chem. 165: 17174.
3. Drummond D.C., et al. (2005) Annu Rev Pharmacol Toxicol. 45: 495-528.
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