Deguelin
Akt inhibitor
Product Specifications
Background
Deguelin is a rotenoid, and a naturally occurring insecticide. Deguelin displays anti-cancer activity by inhibiting the growth of pre-cancerous and cancerous cells (1). High doses may have negative effects on the heart, lungs and nerves however. Deguelin has also been shown to have a correlation with Parkinson's disease in rats (2).
CAS Number
522-17-8
Product Name Alternative
(7aS,13aS) -9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7 (7aH) -one
UNSPSC
41116105
Type
Inducer
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
>98%
Weight
0.05
Format
Cream Solid
Solubility
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Molecular Formula
C23H22O6
Molecular Weight
394.42
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Lee H.Y. (2004) Biochem Pharmacol. 68(6): 1119-1124. 2. Caboni P., et al. (2004) Chem Res. Toxicol. 17(11): 1540-1548.
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