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Apigenin

Protein kinase inhibitor

Product Specifications

Background

Apigenin induces a process called autophagia (1). It is a potent inhibitor of CYP2C9, an enzyme responsible for the metabolism of many pharmaceutical drugs in the body (2). Apigenin has also been shown to reverse the adverse effects of cyclosporine (3).

CAS Number

520-36-5

Product Name Alternative

5,7-Dihydroxy-2- (4-hydroxyphenyl) -4H-chromen-4-one

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

Purity

>98%

Weight

0.01

Format

White Solid

Solubility

Soluble to 50 mM in DMSO

Molecular Formula

C15H10O5

Molecular Weight

270.2

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Ruela-de-Sousa R.R., et al. (2010) Cell Death and Disease. 1(e19): 1-11. 2. Dayong S.I., et al. (2009) Drug Metabolism and Disposition. 37(3): 629-634. 3. Chakravarthi S., Wen C.F., Nagaraja H.S. (2009) J Anal Bio Sci. 32(4): 320-327.

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