Actinomycin D
Transcription inhibitor
Product Specifications
Background
The actinomycins are a class of polypeptide antibiotics. Actinomycin D inhibits transcription by binding DNA at the transcription initiation complex and preventing elongation by RNA polymerase (1). Actinomycin D has been used as a chemotherapy drug (2), and an antibiotic.
CAS Number
50-76-0
Product Name Alternative
2-Amino-N, N'-bis (6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl) -4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
>98%
Weight
0.05
Format
White Solid
Solubility
Soluble to 50 mM in DMSO
Molecular Formula
C62H86N12O16
Molecular Weight
1255.43
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Sobell H. (1985) Proc Natl Acad Sci USA. 82(16): 5328-31. 2. Turan T., et al. (2006) Int J Gynecol Cancer. 16(3): 1432-1438.
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