Camptothecin
Topoisomerase I inhibitor
Product Specifications
Background
Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I. It binds to the topo I and DNA complex, resulting in a tertiary comlex which stabilizes it. This prevents re-ligation and therefore causes DNA damage which results in apoptosis (1-3). It has showed remarkable anti-cancer activity in clinical trials.
CAS Number
7689-03-4
Product Name Alternative
(4S) -4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14 (4H,12H) -dione
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
>98%
Weight
1
Format
Yellow solid
Solubility
Soluble to 5 mM in DMSO
Molecular Formula
C20H16N2O4
Molecular Weight
348.36
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Adams D.J., et al. (2005) Cancer Chem and Pharm. 57(2): 145-154.
2. Redinbo M.R., Stewart L., Kuhn P., Champoux J.J. and Hol W.G.J. (1998) Science. 279:1504-1513.
3. Pommier Y., et al. (2003) Mutat Res. 532: 173-203.
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