Camptothecin

Topoisomerase I inhibitor

Product Specifications

Background

Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I. It binds to the topo I and DNA complex, resulting in a tertiary comlex which stabilizes it. This prevents re-ligation and therefore causes DNA damage which results in apoptosis (1-3). It has showed remarkable anti-cancer activity in clinical trials.

CAS Number

7689-03-4

Product Name Alternative

(4S) -4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14 (4H,12H) -dione

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cancer | Apoptosis

Purity

>98%

Weight

Format

Yellow solid

Solubility

Soluble to 5 mM in DMSO

Molecular Formula

C20H16N2O4

Molecular Weight

348.36

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Adams D.J., et al. (2005) Cancer Chem and Pharm. 57(2): 145-154. 2. Redinbo M.R., Stewart L., Kuhn P., Champoux J.J. and Hol W.G.J. (1998) Science. 279:1504-1513. 3. Pommier Y., et al. (2003) Mutat Res. 532: 173-203.