Cytochalasin D
Actin polymerization inhibitor
Product Specifications
Background
Cytochalasins have the ability to bind to actin filaments and block polymerization and elongation of actin. As a result, they can change cellular morphology, inhibit cellular processes and cause cells to undergo apoptosis (1). Cytochalasin D in particular can inhibit protein synthesis (2).
CAS Number
22144-77-0
Product Name Alternative
(3S,3aR,4S,6S,6aR,7E,10S,12S,13E,15R,15aR) -3-Benzyl-6-hydroxy-4,10,12-trimethyl-5-methylene-1-oxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate, Zygosporin A
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.005
Format
White Solid
Solubility
Soluble to 10 mM in ethanol and to 50 mM in DMSO
Molecular Formula
C30H37NO6
Molecular Weight
507.63
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Haidle A., and Myers A. (2004) Proc Natl Acad Sci. 101(33): 12048-12053. 2. Ornelles et al., (1986) Mol Cell Biol. 6(5): 1650-1662.
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