Epothilone B

Microtubule stabilizer

Product Specifications

Background

Epothilone are a new class of cancer drugs. They prevent cancer cells from dividing by interfering with tubulin (1). Epithilone B possess the same biological effects as paclitaxel in both invitro and cultured cells, because they share the same binding site (2). Epothilone has also been shown to induce tubulin polymerization into microtubules without the presence of GTP. And it also causes cell cycle arrest at the G2-M transition phase, leading to eventual cell apoptosis (3). It is considered Neurotrophic - it has been found to promote axon regeneration.

Product Name Alternative

(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)-1-propen-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione, Patupilone

UNSPSC

41116105

Source

Synthetic

Purity

>98%

Weight

0.001

Format

White Solid

Solubility

Soluble to 10 mM in DMSO

Molecular Formula

C27H41NO6S

Molecular Weight

507.68

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Rosenberg S., Devita V.T., Hellman S. (2005) Cancer: Principles & Practice of Oncology: Lippincott Williams and Wilkins. 2. Julien B., Shah S. (2002) Antimicrob Agents Chemother. 46(9): 2772. 3. Balog D.M., et al. (1996) Angew Chem. 108: 2976. 4. J Ruchel et al. Science 2015, 348: 347-352