Fumonisin B1
Ceramide synthase inhibitor
Product Specifications
Background
Fumonisin B1 is the most prevalent member of a family of toxins. It is hepatotoxic and nephrotoxic in all animal species. It occupies the space and electrostatic interactions of both sphinganine and fatty acyl-CoA (1). Due to this mechanism of action, it has toxic effects in humans such as neural tube defects (2), esophageal cancer, acute mycotoxicosis, and various other carcinogenic effects. Another effect of exposure to FB1 is apoptosis (2).
Product Name Alternative
2,2'-{(19-Amino-11,16,18-trihydroxy-5,9-dimethyl-6,7-icosanediyl)bis[oxy(2-oxo-2,1-ethanediyl)]}disuccinic acid
UNSPSC
41116105
Source
Synthetic
Purity
>98%
Weight
0.005
Format
Beige Solid
Solubility
Soluble to 10 mM in DMSO
Molecular Formula
C34H59NO15
Molecular Weight
721.83
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. European commission (2007). “Fumonisin B1”. Opinion of the scientific committee on food on Fusarium toxins (27).
2. Stockmann-Juvalla H., and Savolainen K. (2008) Human and Exp. Toxicology. 27: 799-809.
CAS Number
116355-83-0
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